Sixth generation (6G)-enabled massive network MANO orchestration, alongside distributed supervision and fully reconfigurable control logic that manages dynamic arrangement of network components, such as cell-free, Open-Air Interface (OAI) and RIS, is a potent enabler for the upcoming pervasive digitalization of the vertical use cases. In such a disruptive domain, artificial intelligence (AI)-driven zero-touch “Network of Networks” intent-based automation shall be able to guarantee a high degree of security, efficiency, scalability, and sustainability, especially in cross-domain and interoperable deployment environments (i.e., where points of presence (PoPs) are non-independent and identically distributed (non-IID)). To this extent, this paper presents a novel breakthrough, open, and fully reconfigurable networking architecture for 6G cellular paradigms, named 6G-BRICKS. To this end, 6G-BRICKS will deliver the first open and programmable O-RAN Radio Unit (RU) for 6G networks, termed as the OpenRU, based on an NI USRP-based platform. Moreover, 6G-BRICKS will integrate the RIS concept into the OAI alongside Testing as a Service (TaaS) capabilities, multi-tenancy, disaggregated Operations Support Systems (OSS) and Deep Edge adaptation at the forefront. The overall ambition of 6G-BRICKS is to offer evolvability, granularity, while, at the same time, tackling big challenges such as interdisciplinary efforts and big investments in 6G integration.