Microelectronics Security - In recent years, information and communication systems have experienced serious security issues due to the rising popularity of image-sharing platforms and the ubiquity of numerous smart electronic devices. The increased volume of data generated by the medical and clinical communities necessitates the use of such advanced platforms for data exchange. As a result, the implementation of improved procedures and resources in terms of storage and security is essential. This research proposes a novel medical image encryption method based on chaos sequence and the modified Twofish algorithm. A quick and more efficient algorithm than current methods is built using chaos-based image encryption methods. The modified algorithm can be applied for hardware applications.