Encryption defined as change information process (which called plaintext) into an unreadable secret format (which called ciphertext). This ciphertext could not be easily understood by somebody except authorized parson. Decryption is the process to converting ciphertext back into plaintext. Deoxyribonucleic Acid (DNA) based information ciphering techniques recently used in large number of encryption algorithms. DNA used as data carrier and the modern biological technology is used as implementation tool. New encryption algorithm based on DNA is proposed in this paper. The suggested approach consists of three steps (conventional, stream cipher and DNA) to get high security levels. The character was replaced by shifting depend character location in conventional step, convert to ASCII and AddRoundKey was used in stream cipher step. The result from second step converted to DNA then applying AddRoundKey with DNA key. The evaluation performance results proved that the proposed algorithm cipher the important data with high security levels.