In recent years, body-worn RFID and NFC (near field communication) devices have become one of the principal technologies concurring to the rise of healthcare internet of thing (H-IoT) systems. Similarly, points of care (PoCs) moved increasingly closer to patients to reduce the costs while supporting precision medicine and improving chronic illness management, thanks to timely and frequent feedback from the patients themselves. A typical PoC involves medical sensing devices capable of sampling human health, personal equipment with communications and computing capabilities (smartphone or tablet) and a secure software environment for data transmission to medical centers. Hybrid platforms simultaneously employing NFC and ultra-high frequency (UHF) RFID could be successfully developed for the first sensing layer. An application example of the proposed hybrid system for the monitoring of acute myocardial infarction (AMI) survivors details how the combined use of NFC and UHF-RFID in the same PoC can support the multifaceted need of AMI survivors while protecting the sensitive data on the patient’s health.